Angioplastia primária de artéria circunflexa anômala após cirurgia de troca valvar mitral / Primary percutaneous coronary intervention of anomalous circumflex artery after mitral valve replacement

A origem anômala da artéria coronária circunflexa do seio de Valsalva direito é a anomalia coronariana mais frequente. Relata-se o caso de uma paciente com artéria circunflexa anômala originada da artéria coronária direita, submetida a cirurgia de troca valvar mitral, evoluindo com choque cardiogênico e oclusão aguda da artéria circunflexa. Foi necessária intervenção coronariana percutânea de emergência e implante de stent não farmacológico. A paciente evoluiu com melhora clínica, sem novas complicações cardíacas...

Anomalous origin of the circumflex coronary artery from the right sinus of Valsalva is the most frequent coronary anomaly. We report the case of a patient with anomalous circumflex artery originating from the right coronary artery, who underwent mitral valve replacement surgery evolving with cardiogenic shock and acute occlusion of the circumflex artery. Emergency percutaneous coronary intervention and bare-metal stent implantation were required. The patient improved clinically without any further cardiaccomplications...

Allosteric inhibition of [[125]I] ET-1 binding to ETA receptors by salicylic acid dimers

Endothelin-1 [ET-1], a potent vasoconstrictor peptide, exerts its physiological effects by binding and activating specific G protein-coupled receptors, named ETA and ETB. An unique property of ET-1 is its ability to bind almost irreversibly to its receptors. Aspirin and salicylic acid [SA] are allosteric inhibitors of ET-1 binding to ETA receptors. Dihalogenated derivatives of SA have been identified as more potent allosteric inhibitors than aspirin. In this study, dihalosalicylic acid dimers were synthesized and tested as inhibitors of [[125]I] ET-1 binding to ETA receptors in rat embryonic cardiomyocyte [H9c2 cell] membranes in aim to development of new potential allosteric inhibitors of ET-1. Some dihalo- salicylic acid dimers synthesized in this study showed promising activity as inhibitor of [[125]I] ET-1 binding to ETA receptors in comparing with the dihalosalicylic acid reported in literature, the bromo substituted compound B showed very interesting activity than other halogen substituted dimers, it causes about 40% inhibition at 100 microM and causes 100% inhibition at 500 microM. we conclude that dihalosalicylic acid dimers can mediate good inhibition activity in comparison to sole dihalosalicylic acid molecule

Inhibition of [[125]I] ET-1 binding to ETA receptors by salicylic acid dimers

Endothelin-1 [ET-1], a potent vasoconstrictor peptide, exerts its physiological effects by binding and activating specific G protein-coupled receptors, named ETA and ATB. A unique property of ET-1 is its ability to bind almost irreversibly to its receptors. Aspirin and salicylic acid [SA] are allosteric inhibitors of ET-1 binding to ETA receptors. Dihalogenated derivatives of SA have been identified as more potent allosteric inhibitors than aspirin. In this study, dihalosalicylic acid dimers were synthesized and tested as inhibitors of [[125]I] ET-1 binding to ETA receptors in rat embryonic cardiomyocyte [H9c2 cell] membranes in aim to development of new potential allosteric inhibitors of ET-1. Some dihalosalicylic acid dimers synthesized in this study showed promising activity as inhibitor of [[125]I] ET-1 binding to ETA receptors in comparing with the dihalosalicylic acid reported in literature. The bromo substituted compound b showed more remarkable activity than other halogen substituted dimers, it causes about 40% inhibition at 100 microM and causes 100% inhibition at 500 microM. We conclude that dihalosalicylic acid dimers can mediate good inhibition activity in comparison to sole dihalosalicylic acid molecule

Evaluation of the effects of rofecoxib and nitric oxide-releasing aspirin on stress-induced gastric ulcers in rats

The study was conducted to investigate possible mechanisms of the protective actions of rofecoxib [a selective COX-2 inhibitor] and nitric oxide-releasing aspirin [NO-aspirin] against experimentally induced gastric lesions in rats. The rats were randomly assigned to vehicle [carboxymethylcellulose], rofecoxib [5 mg/Kg] and NO-aspirin [55mg/Kg]-pretreated groups, in addition to the non-stressed control group. Gastric lesions were induced by exposing the rats to 3 hrs cold restraint stress [CRS] and ulcer indices were determined. Gastric juice parameters [pH, free and total acid output, mucin and pepsin concentrations] were determined. The stomachs were used for determination of gastric mucosal level of lipid peroxides as well as total nitrites. Results showed that both rofecoxib and NO-aspirin displayed protective effects against lesions formation. Pretreatment with both drugs significantly lowered gastric acid secretion, mucin and pepsin concentrations as well as mucosal levels of lipid peroxides and total nitrites compared to CRS rats. This protection was possibly mediated through lowering of gastric juice acid secretion and proteolytic activity and increasing mucin concentration as well as free radical scavenging and reduction of the detrimental increase of nitric oxide during CRS